diff --git a/pkg/analysis_server/test/integration/support/integration_tests.dart b/pkg/analysis_server/test/integration/support/integration_tests.dart
index ae21dc5..8e640e2 100644
--- a/pkg/analysis_server/test/integration/support/integration_tests.dart
+++ b/pkg/analysis_server/test/integration/support/integration_tests.dart
@@ -549,12 +549,19 @@
 
       // Guard against lines like:
       //   {"event":"server.connected","params":{...}}The Dart VM service is listening on ...
-      var dartVMServiceMessage = 'The Dart VM service is listening on ';
+      const dartVMServiceMessage = 'The Dart VM service is listening on ';
       if (trimmedLine.contains(dartVMServiceMessage)) {
         trimmedLine = trimmedLine
             .substring(0, trimmedLine.indexOf(dartVMServiceMessage))
             .trim();
       }
+      const devtoolsMessage =
+          'The Dart DevTools debugger and profiler is available at:';
+      if (trimmedLine.contains(devtoolsMessage)) {
+        trimmedLine = trimmedLine
+            .substring(0, trimmedLine.indexOf(devtoolsMessage))
+            .trim();
+      }
       if (trimmedLine.isEmpty) {
         return;
       }
diff --git a/pkg/dartdev/test/commands/devtools_test.dart b/pkg/dartdev/test/commands/devtools_test.dart
index a8afc94..f6025e2 100644
--- a/pkg/dartdev/test/commands/devtools_test.dart
+++ b/pkg/dartdev/test/commands/devtools_test.dart
@@ -220,7 +220,7 @@
     }) async {
       targetProjectInstance = await targetProject.start(
         [
-          '--disable-dart-dev',
+          '--no-dds',
           '--observe=0',
           if (disableServiceAuthCodes) '--disable-service-auth-codes',
           targetProject.relativeFilePath,
diff --git a/pkg/dds/test/common/test_helper.dart b/pkg/dds/test/common/test_helper.dart
index c0b44d7..2217e12 100644
--- a/pkg/dds/test/common/test_helper.dart
+++ b/pkg/dds/test/common/test_helper.dart
@@ -44,7 +44,7 @@
   final serviceInfoFile = await io.File.fromUri(serviceInfoUri).create();
 
   final arguments = [
-    '--disable-dart-dev',
+    '--no-dds',
     '--observe=0',
     if (!serveObservatory) '--no-serve-observatory',
     if (pauseOnStart) '--pause-isolates-on-start',
diff --git a/pkg/front_end/test/hot_reload_e2e_test.dart b/pkg/front_end/test/hot_reload_e2e_test.dart
index c62383c..ddf0367 100644
--- a/pkg/front_end/test/hot_reload_e2e_test.dart
+++ b/pkg/front_end/test/hot_reload_e2e_test.dart
@@ -95,9 +95,7 @@
       '--enable-vm-service=0', // Note: use 0 to avoid port collisions.
       '--pause_isolates_on_start',
       '--disable-service-auth-codes',
-      // TODO(bkonyi): The service isolate starts before DartDev has a chance
-      // to spawn DDS. We should suppress the Observatory message until DDS
-      // starts (#42727).
+      '--no-dds',
       '--disable-dart-dev',
       outputUri.toFilePath()
     ];
diff --git a/pkg/vm/test/incremental_compiler_test.dart b/pkg/vm/test/incremental_compiler_test.dart
index bf14a4b..72b88c3 100644
--- a/pkg/vm/test/incremental_compiler_test.dart
+++ b/pkg/vm/test/incremental_compiler_test.dart
@@ -503,7 +503,6 @@
         "--pause-isolates-on-exit",
         "--enable-vm-service:0",
         "--disable-service-auth-codes",
-        "--disable-dart-dev",
         list.path
       ]);
 
@@ -607,7 +606,6 @@
         "--pause-isolates-on-exit",
         "--enable-vm-service:0",
         "--disable-service-auth-codes",
-        "--disable-dart-dev",
         list.path
       ]);
 
@@ -873,7 +871,6 @@
         "--pause-isolates-on-exit",
         "--enable-vm-service:0",
         "--disable-service-auth-codes",
-        "--disable-dart-dev",
         list.path
       ]);
 
@@ -955,7 +952,6 @@
         '--enable-vm-service=0', // Note: use 0 to avoid port collisions.
         '--pause_isolates_on_start',
         '--disable-service-auth-codes',
-        '--disable-dart-dev',
         outputFile.path
       ];
       final vm = await Process.start(Platform.resolvedExecutable, vmArgs);
@@ -1363,7 +1359,6 @@
         "--pause-isolates-on-start",
         "--enable-vm-service:0",
         "--disable-service-auth-codes",
-        "--disable-dart-dev",
         scriptOrDill.path
       ]);
 
diff --git a/pkg/vm_service/test/common/utils.dart b/pkg/vm_service/test/common/utils.dart
index 5ab35fa..0d3b2c6 100644
--- a/pkg/vm_service/test/common/utils.dart
+++ b/pkg/vm_service/test/common/utils.dart
@@ -19,7 +19,7 @@
   final serviceInfoFile = await File.fromUri(serviceInfoUri).create();
 
   final arguments = [
-    '--disable-dart-dev',
+    '--no-dds',
     '--observe=0',
     if (!serveObservatory) '--no-serve-observatory',
     if (pauseOnStart) '--pause-isolates-on-start',
diff --git a/pkg/vm_service/test/get_supported_protocols_common.dart b/pkg/vm_service/test/get_supported_protocols_common.dart
index a7be12d..f3bb133 100644
--- a/pkg/vm_service/test/get_supported_protocols_common.dart
+++ b/pkg/vm_service/test/get_supported_protocols_common.dart
@@ -7,22 +7,10 @@
 
 import 'common/test_helper.dart';
 
-/// [expectMissingProtocol] allows for a single protocol to be missing. See
-/// https://github.com/dart-lang/sdk/issues/54835 for context. This test will
-/// fail without this flag on AOT configurations when DDS is expected since DDS
-/// isn't currently setup to run with dart_precompiled_runtime. This flag is
-/// meant to cause this test to fail if
-/// https://github.com/dart-lang/sdk/issues/54841 is resolved so this test can
-/// be updated.
-VMTest expectedProtocolTest(
-  List<String> expectedProtocols, {
-  bool expectMissingProtocol = false,
-}) =>
+VMTest expectedProtocolTest(List<String> expectedProtocols) =>
     (VmService service) async {
       final protocols = (await service.getSupportedProtocols()).protocols!;
-      final expectedLength =
-          expectedProtocols.length - (expectMissingProtocol ? 1 : 0);
-      expect(protocols.length, expectedLength);
+      expect(protocols.length, expectedProtocols.length);
       for (final protocol in protocols) {
         expect(expectedProtocols.contains(protocol.protocolName), true);
         expect(protocol.minor, greaterThanOrEqualTo(0));
diff --git a/pkg/vm_service/test/get_supported_protocols_with_dds_test.dart b/pkg/vm_service/test/get_supported_protocols_with_dds_test.dart
index d2dfb1c..503bd7d 100644
--- a/pkg/vm_service/test/get_supported_protocols_with_dds_test.dart
+++ b/pkg/vm_service/test/get_supported_protocols_with_dds_test.dart
@@ -2,8 +2,6 @@
 // for details. All rights reserved. Use of this source code is governed by a
 // BSD-style license that can be found in the LICENSE file.
 
-import 'dart:io';
-
 import 'common/test_helper.dart';
 import 'get_supported_protocols_common.dart';
 
@@ -13,9 +11,6 @@
       'VM Service',
       'DDS',
     ],
-    // See https://github.com/dart-lang/sdk/issues/54841
-    expectMissingProtocol:
-        Platform.script.toString().endsWith('out.aotsnapshot'),
   ),
 ];
 
diff --git a/pkg/vm_service/test/regress_55559_test.dart b/pkg/vm_service/test/regress_55559_test.dart
index 25248c0..57c4f74 100644
--- a/pkg/vm_service/test/regress_55559_test.dart
+++ b/pkg/vm_service/test/regress_55559_test.dart
@@ -54,7 +54,10 @@
         ],
       );
       final service = await vmServiceConnectUri(wsUri.toString());
-      final vm = await service.getVM();
+      VM vm;
+      do {
+        vm = await service.getVM();
+      } while (vm.isolates!.isEmpty);
       final isolate = vm.isolates!.first;
       final errorCompleter = Completer<RPCError>();
       final stackTraceCompleter = Completer<StackTrace>();
diff --git a/runtime/bin/main_impl.cc b/runtime/bin/main_impl.cc
index 6e2a86f..9e3aa8c 100644
--- a/runtime/bin/main_impl.cc
+++ b/runtime/bin/main_impl.cc
@@ -557,11 +557,8 @@
   result = Dart_SetDeferredLoadHandler(Loader::DeferredLoadHandler);
   CHECK_RESULT(result);
 
-  // We do not spawn the external dds process in the following scenarios:
-  // - The DartDev CLI is disabled and VM service is enabled.
-  // - DDS is disabled.
-  bool wait_for_dds_to_advertise_service =
-      !(Options::disable_dart_dev() || Options::disable_dds());
+  // We do not spawn the external dds process if DDS is explicitly disabled.
+  bool wait_for_dds_to_advertise_service = !Options::disable_dds();
   bool serve_devtools =
       Options::enable_devtools() || !Options::disable_devtools();
   // Load embedder specific bits and return.
diff --git a/runtime/tests/vm/dart/isolates/reload_utils.dart b/runtime/tests/vm/dart/isolates/reload_utils.dart
index a624a33..36ffc6e 100644
--- a/runtime/tests/vm/dart/isolates/reload_utils.dart
+++ b/runtime/tests/vm/dart/isolates/reload_utils.dart
@@ -127,7 +127,7 @@
     if (verbose) '--trace-reload',
     if (verbose) '--trace-reload-verbose',
     '--enable-vm-service:0',
-    '--disable-dart-dev',
+    '--no-dds',
     '--disable-service-auth-codes',
     file
   ];
diff --git a/runtime/tools/heapsnapshot/test/utils.dart b/runtime/tools/heapsnapshot/test/utils.dart
index 67476d3..5917bfc 100644
--- a/runtime/tools/heapsnapshot/test/utils.dart
+++ b/runtime/tools/heapsnapshot/test/utils.dart
@@ -30,6 +30,7 @@
     final processArgs = [
       ...Platform.executableArguments,
       '--disable-dart-dev',
+      '--no-dds',
       '--disable-service-auth-codes',
       '--enable-vm-service:0',
       '--pause-isolates-on-exit',